N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide has been researched along with jnj-7706621 in 1 studies
| Studies (N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide) | Trials (N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide) | Recent Studies (post-2010) (N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide) | Studies (jnj-7706621) | Trials (jnj-7706621) | Recent Studies (post-2010) (jnj-7706621) |
|---|---|---|---|---|---|
| 9 | 0 | 7 | 40 | 0 | 32 |
| Protein | Taxonomy | N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide (IC50) | jnj-7706621 (IC50) |
|---|---|---|---|
| [tau protein] kinase | Oryctolagus cuniculus (rabbit) | 0.0849 | |
| Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Norway rat) | 0.0849 | |
| Aurora kinase A | Homo sapiens (human) | 0.011 | |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | 1.4805 | |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | 0.0062 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | 0.0849 | |
| Epidermal growth factor receptor | Homo sapiens (human) | 0.0849 | |
| Insulin receptor | Homo sapiens (human) | 0.0849 | |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | 0.0537 | |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | 0.0849 | |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Norway rat) | 0.0849 | |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | 0.11 | |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | 0.0652 | |
| Cyclin-A2 | Homo sapiens (human) | 0.0731 | |
| Fibroblast growth factor receptor 2 | Homo sapiens (human) | 0.1042 | |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | 0.11 | |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | 0.0575 | |
| G1/S-specific cyclin-D1 | Mus musculus (house mouse) | 0.0849 | |
| Cyclin-dependent kinase 4 | Mus musculus (house mouse) | 0.0849 | |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | 0.13 | |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | 0.041 | |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | 0.041 | |
| Mitogen-activated protein kinase 1 | Rattus norvegicus (Norway rat) | 0.0849 | |
| Cyclin-A1 | Homo sapiens (human) | 0.002 | |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | 0.0062 | |
| Cyclin-dependent kinase 3 | Homo sapiens (human) | 0.058 | |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | 0.0126 | |
| Casein kinase I isoform delta | Rattus norvegicus (Norway rat) | 0.0849 | |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | 0.0062 | |
| Aurora kinase B | Homo sapiens (human) | 0.0095 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
1 other study(ies) available for N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide and jnj-7706621
| Article | Year |
|---|---|
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |